ZnxCu0.5-xMg0.5Fe2O4 nanoparticles: A biocompatible platform for magnetic hyperthermia

초록

This investigation explores the potential of Zn-Cu-Mg ferrite nanoparticles, specifically ZnxCu0.5-xMg0.5Fe2O4 with varying Zn content (x = 0.15, 0.25, and 0.35, denoted as Sa, Sb, and Sc), for magnetic hyperthermia. The study aimed to characterize their structural, magnetic, and biological properties. To determine the crystalline structure, X-ray diffraction was performed. Elemental composition was verified using energy-dispersive X-ray spectroscopy. Transmission electron microscopy revealed the nanoparticles to be nearly spherical, with diameters within the 11-13 nm range. Fourier-transform infrared spectroscopy confirmed the presence of relevant functional groups. Magnetic properties were assessed using a vibrating sample magnetometer, revealing saturation magnetization values of 60.60 emu/g (Sa), 61.54 emu/g (Sb), and 58.29 emu/g (Sc). The heating efficiency, quantified as the specific absorption rate at 316 kHz, reached a maximum of 169.04 W/g, demonstrating effective heat generation. Biocompatibility was evaluated through cytotoxicity assays on normal human dermal fibroblasts and human breast cancer cells. The nanoparticles exhibited high cell viability, exceeding 85 %, indicating good compatibility with biological systems. The combination of favorable magnetic heating capabilities and demonstrated biocompatibility suggests these Zn-Cu-Mg ferrite nanoparticles hold significant promise as a safe and effective platform for magnetic hyperthermia applications.

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