Evaluating Mg2*- doped Cu-Zn ferrite nanoparticles for hyperthermia and their biocompatibility in normal and cancer cells

초록

This study explores the synthesis of MgxZn0.5Cu0.5-xFe2O4 (x = 0.1, 0.2, and 0.3) nanoparticles (NPs) using a solvothermal reflux technique. The samples, labeled as MZC1 (x = 0.1), MZC2 (x = 0.2), and MZC3 (x = 0.3), were characterized to determine their structural, compositional, and magnetic properties. Additionally, their specific absorption rate (SAR) measured and biocompatibility were evaluated using human breast cancer cells (MDA-MB-231) and normal mouse muscle fibroblast cells (BLO-11). Results indicated that the NPs exhibited superparamagnetic behavior with an average particle size ranging from 14 to 16 nm. The saturation magnetization (Ms) demonstrated variation with Mg2* doping levels in the Cu-Zn system, peaking at 65.35 emu/g and 65.88 emu/g for MZC1 and MZC2, before declining to 56.93 emu/g for MZC3. Hyperthermia performance, evaluated under an alternating magnetic field (AMF) of 18.49 kA/m at a frequency of 316 kHz, revealed a decrease in the SAR as the Mg2* concentration increased. MZC1 exhibited the highest SAR of 197.87 W/g at a ferrofluid concentration of 1 mg/mL. These findings demonstrate that Mg2+ doping significantly influences the microstructure, magnetic behavior, SAR, and biocompatibility of the NPs highlighting their potential for use in MH therapy.

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