Synergistic role of Mnx incorporation in Ni0.5-xZn0.5Fe2O4 ferrite nanoparticles: Structural, magnetic, hyperthermia, and cytocompatibility insights

초록

MnxNi0.5-xZn0.5Fe2O4 (x = 0.1-0.3) nanoparticles, denoted as MNZFe-1, MNZFe-2, and MNZFe-3, were synthesized and systematically characterized. X-ray diffraction confirmed a well-crystalline spinel ferrite structure with an increase in lattice constant and crystallite size upon Mn incorporation, owing to the larger ionic radius of Mn2+. TEM and DLS analyses revealed slightly enlarged particle sizes but reduced hydrodynamic diameters, indicating dopant-induced growth modification. XPS verified the presence of Mn, Ni, Zn, Fe, and O with mixed oxidation states. Magnetic measurements demonstrated superparamagnetic behavior, with the highest saturation magnetization (Ms = 68.61 emu/g) observed for MNZFe-3. Under an alternating magnetic field (AMF), MNZFe-1 exhibited superior hyperthermia performance, while cytocompatibility assays confirmed minimal toxicity toward murine colorectal carcinoma (CT-26) cancer cell lines and normal mouse muscle fibroblast (BLO-11) cell lines. The nanoparticles also exhibited excellent biocompatibility, suggesting their safe use in medical applications. These findings highlight the tunable nature of Mn-Ni-Zn ferrites and point toward future work optimizing particle composition, size, and surface functionalization to enhance therapeutic efficiency and broaden biomedical applications.

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